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MOTS-c
Mitochondrial ORF of 12S rRNA Type-c
Low Risk
Mitochondrial EnergyFat LossAnti-Aging
A 16-amino acid peptide encoded by mitochondrial DNA. Acts as an "exercise mimetic" that enhances metabolism and activates AMPK pathways.
Benefits
Exercise mimetic (mimics benefits of physical exercise)
Stimulates glucose utilization and fat oxidation
Improves insulin sensitivity (AMPK pathway)
Reduces inflammation
Improves exercise capacity
Promotes stress resistance
Side Effects & Risks
Generally well toleratedmild
Injection site irritationmild
Mild fatigue initiallymild
Rare muscle crampingmild
Dosing Information
Typical Dose
5-15 mg/week, split 2-3 injections
Administration
Subcutaneous injection
Cycle Length
2-4 weeks on, 2-4 weeks off
Notes
Typically Mon/Wed/Fri dosing.
Legal Status
FDA Status
Not FDA-approved
Availability
Research peptide suppliers
WADA Status
Banned by WADA (athletes beware)
Evidence
Evidence LevelLow-Moderate
Published in Nature Communications (2020) with strong mechanistic data. However, zero completed human clinical trials. All dosing protocols are extrapolated from animal data. USADA explicitly warns "it is unknown under what conditions (if any) it is safe to use."
Works Well In These Stacks
Where to Buy
Available from verified suppliers
MetaVitality Labs Verified4.7
View Supplier MOTS-c Mitochondrial Peptide
LyophilizedPurity: 99%+
COA Available Third-Party TestedIn Stock
PeptideLab Sciences Verified4.8
View Supplier MOTS-c Research Vial
LyophilizedPurity: 99%+
COA Available Third-Party TestedIn Stock