Melanotan II

Also known as: MT-II, MT2, Barbie Drug

High Risk

Skin & HairSexual Health

A synthetic melanocyte-stimulating hormone analog. Induces tanning without UV. Viral as "Barbie drug" but carries significant safety concerns including melanoma risk. ILLEGAL in US and UK.

Benefits

Induces tanning within ~5 doses without UV

Increases sexual arousal and libido

May provide some UV protection via melanin

Side Effects & Risks

Nausea and vomiting (common)moderate

Facial flushingmild

Increased moles and frecklesmoderate

SERIOUS: Potential melanoma/skin cancer riskserious

SERIOUS: Renal infarction (potentially fatal)serious

SERIOUS: Brain swelling reportedserious

Dosing Information

Typical Dose

250-500 mcg initially, maintenance 500 mcg/week

Administration

Subcutaneous injection

Cycle Length

Loading then maintenance

Notes

NON-SELECTIVE melanocortin agonist. Primary safety concern.

Legal Status

FDA Status

NOT FDA-approved; illegal to purchase in US and UK

Availability

Sold illegally online despite bans

WADA Status

Banned by WADA (athletes beware)

Evidence

Evidence LevelModerate

Development abandoned due to safety concerns. Health agencies globally advise against use. 2025 case report linked nasal spray use to oral mucosal malignant melanoma. Non-selective melanocortin agonist with unpredictable systemic effects.