Kisspeptin

Kisspeptin-10

Also known as: KP-10, KISS1

Low Risk

Sexual Health

Stimulates GnRH release, increasing LH, FSH, and testosterone. Well-studied in IVF for egg maturation. Theoretical HCG alternative during TRT but not yet tested in that context.

Benefits

Stimulates natural LH and FSH production

Increases testosterone via HPG axis

Dose-dependent egg maturation (proven in IVF trials)

Enhances sexual desire/arousal (shown in brain imaging studies)

Theoretical fertility maintenance during TRT (not yet tested)

Side Effects & Risks

Flushing and warmth (common, resolves quickly)mild

Very well tolerated in human studiesmild

Dosing Information

Typical Dose

100-200 mcg, 2-3 times per week

Administration

Subcutaneous injection

Cycle Length

Ongoing concurrent with TRT

Notes

Often used alongside TRT to maintain fertility.

Legal Status

FDA Status

Not FDA-approved; used in clinical research

Availability

Specialized clinics and research institutions

WADA Status

Not currently banned

Evidence

Evidence LevelModerate-High

Multiple human RCTs published in JCEM and JCI. Well-validated IVF trigger. LH/FSH stimulation well-documented. TRT fertility maintenance is theoretical only — no published trial.